I have neuropathy in my toes and at night is when they seem to get cold and bother some. I was using a heating pad but in the middle of my sleep it was too warm or my leg would be wrapped around the cord. The night I received them I put them on at bedtime ( these socks are only going to be for bedtime in my case) and my toes stay warm and no more heating pad. I might add I was worried about the string at the top of the cuff, you know the one that always makes you ankles look like a hot dog casing at the ends. Well these do not do that, the edema in my legs do not show any signs of wearing these socks in the morning nor do they cut off circulation. And they are 4 pairs for under $20 aprox, so I think thats a good value.